Non-invasive prenatal testing for aneuploidy screening

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Aneuploidy screening by non‐invasive prenatal testing in twin pregnancy

OBJECTIVES To describe our experience with non-invasive prenatal testing (NIPT) in twin pregnancy. METHODS Two sets of maternal blood samples from twin pregnancies were analyzed at our laboratory using NIPT: 115 stored samples from pregnancies with known outcome (Clinical Study A) and 487 prospectively collected samples for which outcomes were requested from providers (Clinical Study B). NIPT...

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Non-invasive prenatal testing for aneuploidy and beyond: challenges of responsible innovation in prenatal screening. Summary and recommendations.

Wybo Dondorp*,1, Guido de Wert1, Yvonne Bombard2, Diana W Bianchi3, Carsten Bergmann4,5, Pascal Borry6, Lyn S Chitty7, Florence Fellmann8, Francesca Forzano9, Alison Hall10, Lidewij Henneman11, Heidi C Howard12, Anneke Lucassen13, Kelly Ormond14, Borut Peterlin15, Dragica Radojkovic16, Wolf Rogowski17, Maria Soller18, Aad Tibben19, Lisbeth Tranebjærg20,21,22, Carla G van El11 and Martina C Corn...

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Non-invasive prenatal testing.

BACKGROUND Non-invasive prenatal testing (NIPT), also known as cell-free DNA testing and non-invasive prenatal screening (NIPS), is an important addition to the range of screening tests for fetal chromosomal abnormalities. For trisomy 21 in particular, NIPT is superior to other screening modalities. However, NIPT has limitations and complexities that requesting clinicians and their patients sho...

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P-226: Non-Invasive Prenatal Screening for Fetal Chromosomal Anomalies in South of Iran

Background: Prenatal diagnosis for Fetal Chromosomal anomalies currently relies on assessment of risk followed by a combination of biochemical and nuchal translucency. Trisomy 21 is the most common trisomy that is associated with intellectual disability. Pregnant women who receive a prenatal diagnosis of trisomy 21 currently have the option of continuing or terminating their pregnancy, but no f...

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Attitudes Towards Non-Invasive Prenatal Testing for Aneuploidy Among United States Adults of Reproductive Age

Objective(s)—To determine how adults in the United States (US) view non-invasive prenatal testing using cell-free fetal DNA (cffDNA testing) in order to help estimate uptake. Study Design—A national sample of 1,861 US-based adults was surveyed using a validated online survey instrument. The survey was administered by a commercial survey research company. Respondents were randomized to receive a...

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ژورنال

عنوان ژورنال: BMJ

سال: 2020

ISSN: 1756-1833

DOI: 10.1136/bmj.m3930